Spondyloarthritis & psoriatic arthritis
Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study
Authors' conclusion
This prospective study emphasizes the impact of pain catastrophizing on drug retention in patients with PsA and axSpA.
Study context
- Population
- Patients with Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA), multicenter GIRRCS study, Italy
- Participants
- 135 vs 71
- Exposure
- Drug discontinuation vs drug retention, by pain catastrophizing
- PsAn = 135
- axSpAn = 71
- Outcome
- Drug retention (factors associated with drug discontinuation)
- Follow-up
- Two years
Methodological detailsmulticenter, observational, two-year follow-up
- Multicenter
- Observational
- Two-year follow-up
Main finding
As reported in the abstract
Drug discontinuation in PsA
- PsA: pain catastrophizing (Helplessness, Magnification, Rumination) significantly elevated in patients who interrupted treatment
- PsA: pain catastrophizing an independent predictor of drug suspension within two years (multivariable analysis)
- PsA: early discontinuers had higher baseline disease activity and higher incidence of comorbid FM
Observational data: associations, not effects.
Further findings
Drug discontinuation in axSpA
- axSpA: discontinuation associated with female gender, shorter disease duration, higher baseline disease activity and elevated pain catastrophizing
- axSpA: univariable analysis supported pain catastrophizing, including its domains, as predictors of treatment interruption
- Limited events in axSpA patients precluded a multivariate analysis
Original publication
Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study. Arthritis Res Ther. Published 18 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →