Lupus & antiphospholipid syndrome
Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine
Main finding · Childhood infection requiring hospital management (adjusted)Result — go to the resultOdds ratio 2.283 CI 1.003–5.198Authors' conclusion
There were no significant negative outcomes in children exposed to HCQ in pregnancy. AZA use was associated with increased reporting of childhood infection, which warrants further study.
Study context
- Population
- Women attending UK specialist lupus clinics with children ≤17 years old, born after SLE diagnosis; 10 UK centreslive births of 199 mothers
- Participants
- 284 live births
- Exposure
- Children exposed vs not exposed to HCQ or AZA during pregnancy and breast-feeding
- HCQn = 150
- AZAn = 87
- Outcome
- Outcomes of children born to mothers with SLE exposed to HCQ or AZA during pregnancy and breast-feeding (low birth weight, childhood infection)
Methodological detailsmulticentre, multivariable mixed-effects logistic regression
- Multicentre
- Multivariable mixed-effects logistic regression
Main finding
As reported in the abstract
Childhood infection requiring hospital management (adjusted)
Odds ratio
2.283
CI 1.003–5.198
P = 0.049
AZAvs Not exposed
OR 2.283 (CI 1.003–5.198); P = 0.049
Observational data: associations, not effects.
Further findings
Congenital malformations or intrauterine growth restriction
- No significant differences between children exposed or not to HCQ or AZA
AZA use by maternal history
- AZA use increased in women with a history of hypertension or renal disease
Original publication
Outcomes of children born to mothers with systemic lupus erythematosus exposed to hydroxychloroquine or azathioprine. Rheumatology (Oxford). Published 29 June 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →