Lupus & antiphospholipid syndrome
Neutrophil gelatinase-associated lipocalin (NGAL) in lupus nephritis and beyond
Authors' conclusion
Blood levels of NGAL are increased in patients with SLE with decreased kidney function, and in those with secondary APS.
Study context
- Population
- Two independent Swedish SLE cohorts, disease controls and healthy controlstwo SLE cohorts plus controls
- Participants
- 124 / 308 / 38 / 77
- Exposure
- SLE vs disease controls and healthy controls
- SLE exploratoryn = 124
- SLE validationn = 308
- Disease controlsn = 38
- Healthy controlsn = 77reference
- Outcome
- NGAL levels in peripheral blood (ELISA)
Methodological detailsexploratory and validation cohorts, in vitro mechanistic experiments
- Exploratory and validation cohorts
- In vitro mechanistic experiments
Main finding
As reported in the abstract
Serum NGAL, SLE vs healthy controls (exploratory cohort)
- SLE exploratory vs Healthy controls: P = 0.021
Observational data: associations, not effects.
Further findings
Serum NGAL, SLE vs healthy controls (exploratory cohort)
- Serum NGAL increased in SLE vs healthy controls
- P = 0.021
Serum NGAL and histologically proven membranoproliferative lupus nephritis (LN) (exploratory cohort)
- Serum NGAL associated with membranoproliferative LN
- P = 0.018
Plasma NGAL in history of LN and in secondary antiphospholipid syndrome (APS) (validation cohort)
- Plasma NGAL elevated in history of LN
- P = 0.0048
- Plasma NGAL elevated in SLE with secondary APS vs without
- P = 0.0022
NGAL discrimination of creatinine clearance <60 mL/min (CKD stage 3 or more)
- AUC, exploratory and validation cohort, respectively
- 0.92 (p<0.0001) and 0.94 (p=0.0088)
- High accuracy in both cohorts
NGAL secretion by immune complexes (IC)-stimulated neutrophils
- Neutrophils stimulated with IC secrete more NGAL vs baseline; blocked by adding a TLR8i
Original publication
Neutrophil gelatinase-associated lipocalin (NGAL) in lupus nephritis and beyond. Lupus Sci Med. Published 14 January 2025. doi:10.
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