Myositis‐Associated Autoantibodies in Patients With Juvenile Myositis Are Associated With Refractory Disease and Mortality
Authors' conclusion
MAAs were prevalent in a large cohort of patients with juvenile myositis. ILD, refractory disease, and mortality were associated with MAA positivity.
Study context
- Population
- Patients with juvenile myositis in cross-sectional natural history studies tested for myositis autoantibodies
- Participants
- 551 patients
- Exposure
- MAA positive vs MAA negative
- Outcome
- MAA prevalence
Methodological detailscross-sectional natural history studies, multivariable logistic regression
- Cross-sectional natural history studies
- Multivariable logistic regression
Main finding
As reported in the abstract
Had an MAA
36%
Had more than one MAA
13%
Observational data: associations, not effects.
Further findings
Overlap myositis
Overlap myositis
- Higher frequency of overlap myositis among MAA positive, P < 0.001
Raynaud phenomenon, association with MAA positivity
- OR
- 2.44 (95% CI 1.41-4.28)
Interstitial lung disease (ILD), association with MAA positivity
- OR
- 3.43 (95% CI 1.75-6.96)
Chronic disease course, association with MAA positivity
- OR
- 1.72 (95% CI 1.10-2.72)
Mortality, association with MAA positivity
- OR
- 3.76 (95% CI 1.72-8.43)
Mortality, association with number of myositis-associated autoantibodies (MAAs)
- OR
- 1.83 (95% CI 1.16-2.86)
- Multivariable logistic regression
Original publication
Myositis‐Associated Autoantibodies in Patients With Juvenile Myositis Are Associated With Refractory Disease and Mortality. Arthritis Rheumatol. Published 12 March 2024. doi:10.
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