Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial
Authors' conclusion
Younger PARTNER participants showed greater functional improvement compared to older age groups (moderating effect). Additionally, indirect mediation effects suggest increased satisfaction across the three satisfaction domains led to reduced knee pain and enhanced function.
Study context
- Population
- People with knee osteoarthritis (OA) in primary care
- Participants
- 217 people
- Comparison
- PARTNER vs usual GP-delivered care
- PARTNERn = 112
- Usual caren = 105reference
- Primary endpoint
- Moderators and mediators of change in knee pain (NRS 0-10, higher worse) and function (KOOS function subscale 0-100, higher better)
- Follow-up
- 12 months
Methodological detailsexploratory moderator and mediation analysis
- Exploratory moderator and mediation analysis
Primary result
As reported in the abstract
Moderators and mediators of change in pain and function
- Age moderated change in function: intervention participants <50 years had greater functional improvement than older counterparts vs control; coefficient, 50-69 years
- −32.88 (95% CI −45.02 to −20.74)
- Age moderation of function: coefficient, ≥70 years
- −24.28 (95% CI −36.53 to −12.02)
- Indirect effect of overall satisfaction on mean change in pain
- −0.10
- Indirect effect of treatment-related satisfaction on mean change in pain
- −0.06
- Indirect effect of symptom-related satisfaction on mean change in pain
- −0.08
- Indirect effect of overall satisfaction on function
- 0.09
- Indirect effect of treatment-related satisfaction on function
- 0.05
- Indirect effect of symptom-related satisfaction on function
- 0.07
Original publication
Moderators and Mediators of Pain and Function Outcomes in a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: Secondary Exploratory Analysis of a Randomized Controlled Trial. Arthritis Care Res (Hoboken). Published 7 July 2025. doi:10.
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