Mitochondria-centred metabolomic map of inclusion body myositis: sex-specific alterations in central carbon metabolism
Authors' conclusion
IBM is associated with clinically significant alterations in central carbon metabolism, with the strongest RNA-metabolomic-clinical correlations observed in males.
Study context
- Population
- Inclusion body myositis (IBM) patients and controls without myopathy, muscle tissue with prior bulk RNA sequencing
- Participants
- 37 vs 22
- Comparison
- IBM muscle vs muscle of controls without myopathy
- IBMn = 37
- Controlsn = 22reference
- Outcome
- Metabolomic signatures of IBM in muscle tissue, sex-specific differences and correlation with clinical parameters
Methodological detailsdiscovery metabolite screening, quantitative targeted metabolomics, RNA-metabolomic integration
- Discovery metabolite screening
- Quantitative targeted metabolomics
- RNA-metabolomic integration
Main finding
As reported in the abstract
RNA-metabolomic integrated modules with significant correlations
4
Modules correlated with manual muscle test (MMT)
3
Modules correlated with p-S65-Ubiquitin (p-S65-Ub)
2
Original publication
Mitochondria-centred metabolomic map of inclusion body myositis: sex-specific alterations in central carbon metabolism. Ann Rheum Dis. Published 30 May 2025. doi:10.
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