Lupus & antiphospholipid syndrome
Lupus enteritis: A 10-year experience in a single Latin American center
Main finding · Factors independently associated with LE (multivariable)Result — go to the resultOdds ratio per higher SLEDAI-2K score 1.10 95% CI 1.02–1.18Authors' conclusion
In patients of Mestizo ethnicity, LE occurs during the early course of SLE, frequently is one of the presenting manifestations of SLE, and in most cases, it presents with concomitant lupus nephritis. Higher levels of disease activity at diagnosis were independently associated with LE occurrence and when recurrences occur, they do so in the context of severe wall thickness.
Study context
- Population
- Hospitalized systemic lupus erythematosus (SLE) patients admitted to a tertiary hospital in Latin America, January 2012–December 2021; all of Mestizo ethnicity2,479 SLE inpatients screened
- Participants
- 16 vs 48
- Comparison
- SLE patients with lupus enteritis (LE) vs without LE
- LEn = 16
- Non-LEn = 48reference
- Outcome
- Factors associated with occurrence of LE
Methodological detailssingle-centre, matched (1:3) for sex and birth year, univariable and multivariable logistic regression
- Single-centre
- Matched (1:3) for sex and birth year
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Odds ratio per higher SLEDAI-2K score
1.10
95% CI 1.02–1.18
P = 0.015
Observational data: associations, not effects.
Further findings
Disease duration
Hospital LOS · significantly longer in LE
P < 0.001
| Outcome | LE | Non-LE | P value |
|---|---|---|---|
| SLEDAI-2K score | 20.5 ± 9.4 | 9.8 ± 10.4 | P < 0.001 |
Frequency of LE among hospitalised SLE patients
- Of 2,479 SLE inpatients, 16 diagnosed with LE
- 0.65%
SLE diagnosed simultaneously with first LE episode
- Patients with SLE diagnosed at first LE episode
- 10 (62.5%)
Time from SLE diagnosis to first LE episode
- Median time, months (IQR 0-78)
- 7
Concomitant LN in LE patients
- Most LE patients had concomitant LN
- 93.8%
LE recurrence
- Recurrence, both with bowel wall thickening > 8 mm
- 2 (12.5%)
Intestinal pseudo-obstruction in large intestine-dominant LE
- Both patients with large intestine-dominant LE developed intestinal pseudo-obstruction
- 2
Safety
- Intestinal pseudo-obstruction in large intestine-dominant LE
- 2 · events
- Life-threatening complications (intestinal hemorrhage, infarction, perforation) and deaths directly due to LE
- 0 · events
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →