Autoinflammatory & rare systemic diseases
Lung disease in adult-onset Still’s disease: a Chinese cohort study
Main finding · MASResult — go to the resultHazard ratio 2.62 95% CI 1.38–4.96Authors' conclusion
AOSD-LD defines a severe disease phenotype and serves as a critical independent predictor for life-threatening MAS and chronic relapse.
Study context
- Population
- Chinese cohort of patients with AOSD
- Participants
- 209 participants
- Exposure
- AOSD-related lung disease vs no lung disease
- AOSD-LDn = 49
- Outcome
- MAS and disease relapse
Methodological detailsmultivariable Cox regression, subgroup analyses
- Multivariable Cox regression
- Subgroup analyses
Main finding
MAS
Hazard ratio
2.62
95% CI 1.38–4.96
P = 0.0041
AOSD-LDvs Non-lung disease
HR 2.62 (95% CI 1.38–4.96); P = 0.0041
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Disease relapse (multivariable Cox) | 2.66 (1.50–4.71) | P = 0.0012 | |
| 0.20.5125Hazard ratio (log scale) |
Lung involvement in the AOSD cohort (prevalence)
- Lung involvement identified
- 49 (23.4%)
- Asymptomatic
- 69.4%
Risk factor for AOSD-LD
- Pleuritis was the strongest independent risk factor of AOSD-LD
- P < 0.0001
Radiographic patterns of AOSD-LD and outcomes
- Acute exudative pattern strongly associated with early macrophage activation syndrome (MAS) development
- P = 0.0315
- Interstitial pattern associated with a chronic, refractory course
- P = 0.0059
- Acute exudative pattern most prevalent, followed by interstitial and suspected pulmonary hypertension (PH) patterns
Original publication
Lung disease in adult-onset Still’s disease: a Chinese cohort study. Rheumatology (Oxford). Published 17 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →