Lupus & antiphospholipid syndrome
LUNELORD: A descriptive, prospective study on the demographics, disease characteristics and health-related quality of life of patients with LUpus NEphritis and long-term ORgan damage in rheumatology clinics in the Arabian Gulf
Authors' conclusion
LUNELORD demonstrated a substantial burden of LN disease among patients and highlighted variable adherence to international management and treatment guidelines among rheumatologists in the Arabian Gulf.
Study context
- Population
- Adult patients with LN at rheumatology centres in the UAE, Qatar, Oman and Kuwait
- Participants
- 193 patients
- Outcome
- Demographics, clinical characteristics, treatment patterns and health-related quality of life (HRQoL) (SF-36) of patients with LN
- Follow-up
- Up to 12 months
Methodological detailsmulticentre, 12 months of routine-care follow-up, retrospective chart abstraction up to 12 months before enrolment
- Multicentre
- 12 months of routine-care follow-up
- Retrospective chart abstraction up to 12 months before enrolment
Main finding
As reported in the abstract
Characteristics and outcomes of patients with LN
- Female
- 83.9%
- Arab ethnicity
- 85.0%
- Age, mean (SD), years
- 37.2 (10.4)
- Renal biopsy performed
- 123 (64.4%)
- ISN/RPS class V
- 23.4%
- ISN/RPS class IV
- 22.7%
- ISN/RPS class III
- 20.6%
- HCQ at baseline
- 96.4%
- Prednisolone at baseline
- 78.8%
- MMF at baseline
- 69.3%
- Renal remission during follow-up
- 123 (63.7%)
- End-stage renal disease
- 12/177 (6.8%)
Observational data: associations, not effects.
Further findings
Association of reduced anti-dsDNA levels with renal remission · Months 3, 6 and 9
- Significant association between reduced anti-dsDNA levels and renal remission
SF-36 general health domain score, mean (SD) change from baseline · Month 12
- Change in general health domain score, mean (SD)
- +9.5 [42.5]; p = 0.002
- Overall SF-36 and other domain scores remained constant
Original publication
LUNELORD: A descriptive, prospective study on the demographics, disease characteristics and health-related quality of life of patients with LUpus NEphritis and long-term ORgan damage in rheumatology clinics in the Arabian Gulf. Lupus. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →