Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation
Authors' conclusion
A significant bidirectional association exists between RA and COPD and it is partially mediated by systemic inflammation.
Study context
- Population
- UK Biobank participantsUK Biobank
- Participants
- 403,045 participants
- Exposure
- RA vs no RA for future chronic obstructive pulmonary disease (COPD), and COPD vs no COPD for future RA
- RAn = 4,755
- COPDn = 6,989
- Outcome
- Longitudinal reciprocal association between RA and COPD
Methodological detailscross-lagged panel model, Cox proportional hazards regression, logistic regression, causal mediation analysis
- Cross-lagged panel model
- Cox proportional hazards regression
- Logistic regression
- Causal mediation analysis
Main finding
As reported in the abstract
Bidirectional RA–COPD association (cross-lagged panel model, adjusted)
RA→COPD path β
0.018
P < 0.001
COPD→RA path β
0.010
P < 0.001
Observational data: associations, not effects.
Further findings
Future COPD in non-COPD population
| Estimate | ||
|---|---|---|
| RACox model | HR 1.65 (95% CI 1.50–1.83) | |
| RALogistic model | OR 1.85 (95% CI 1.66–2.07) | |
| 0.512Ratio (log scale) |
RA during follow-up in non-RA population
| Estimate | ||
|---|---|---|
| COPDCox model | HR 1.67 (95% CI 1.44–1.92) | |
| COPDLogistic model | OR 1.70 (95% CI 1.47–1.97) | |
| 0.512Ratio (log scale) |
Mediation by systemic inflammatory biomarkers
- Five inflammatory factors mediated the RA→COPD path
- CRP mediated the COPD→RA path
- False discovery rate < 0.05
Original publication
Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation. Rheumatology (Oxford). Published 6 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →