Synovial Tissue Heterogeneity in Japanese Patients With Rheumatoid Arthritis Elucidated Using a Cell‐Type Deconvolution Approach
Authors' conclusion
This study adds insights into the synovial heterogeneity in East Asian patients and shows a promising link with predominant inflammatory signals.
Study context
- Population
- East Asian patients in Japan with rheumatoid arthritis (RA) undergoing articular surgery
- Participants
- 41 synovial tissues
- Outcome
- Synovial subtypes by cellular composition
Methodological detailscell-type deconvolution using a public single-cell-based reference, gene set variation analysis, ATAC-sequencing, hierarchical clustering
- Cell-type deconvolution using a public single-cell-based reference
- Gene set variation analysis
- ATAC-sequencing
- Hierarchical clustering
Main finding
As reported in the abstract
- RA synovium stratified into three distinct subtypes by hierarchical clustering of cellular composition
- 3
Original publication
Synovial Tissue Heterogeneity in Japanese Patients With Rheumatoid Arthritis Elucidated Using a Cell‐Type Deconvolution Approach. Arthritis Rheumatol. Published 5 November 2023. doi:10.
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