Longitudinal analysis of serum urate in prediabetic phase
Authors' conclusion
Among individuals with prediabetes, several baseline variables were significant predictors of increased SU levels over time.
Study context
- Population
- Individuals with prediabetes (initial haemoglobin A1c (HbA1c) 5.7%–6.4%) with at least one serum urate (SU) test before and after diagnosis, academic health system, 2007–20226,832 SU observations
- Participants
- 1,521 individuals
- Outcome
- Longitudinal SU trends during follow-up (multivariable mixed-effects model; censored at diabetes onset)
Methodological detailselectronic health records, multivariable mixed-effects model, single academic health system
- Electronic health records
- Multivariable mixed-effects model
- Single academic health system
Main finding
As reported in the abstract
Longitudinal SU trends
Baseline median SU
6.3 mg/dl
Median follow-up
7.4 years
Observational data: associations, not effects.
Further findings
SU by BMI subgroup
- BMI ≥30 kg/m² had higher SU levels than lower BMI
Original publication
Longitudinal analysis of serum urate in prediabetic phase. Rheumatology (Oxford). Published 14 August 2024. doi:10.
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