Analysis of Gout Remission Definitions in a Randomized Controlled Trial of Colchicine Prophylaxis for People With Gout Initiating Allopurinol
Authors' conclusion
Using either definition, 6 months of colchicine prophylaxis when initiating ULT does not provide an advantage in the fulfillment of gout remission. People fulfilling either definition report fewer symptoms, less concern about their gout, and, when using the simplified definition, are less affected by gout.
Study context
- Population
- People with gout commencing allopurinol (urate-lowering therapy (ULT))
- Participants
- 200 people
- Comparison
- Colchicine 0.5 mg daily prophylaxis for 6 months vs placebo in people with gout commencing allopurinol
- Primary endpoint
- Gout remission by the 2016 preliminary definition or simplified definition without patient-reported outcomes
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Further findings
Gout remission, simplified definition · first 6 months
Gout remission, 2016 preliminary definition, after study drug discontinuation · second 6 months
P = 0.03
Gout remission, simplified definition, after study drug discontinuation · second 6 months
P = 0.02
Illness perceptions (gout-specific Brief Illness Perception Questionnaire) in people in remission
- Participants in remission by either definition had more favorable perceptions about gout symptoms and illness concerns, and about consequences with the simplified definition
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →