Lupus & antiphospholipid syndrome
Long-Term Opioid Therapy Among Patients With Systemic Lupus Erythematosus in the Community: A Lupus Midwest Network (LUMEN) Study
Authors' conclusion
Patients with SLE are more likely to receive LTOT than controls. Among patients with SLE, LTOT was associated with pericarditis and several comorbidities. However, LTOT was not associated with CKD despite the limited pain control options among these patients.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and matched controls without SLE in a population-based cohort (Lupus Midwest Network) on January 1, 2015matched cohort
- Participants
- 465 vs 465
- Exposure
- SLE vs matched controls without SLE
- SLEn = 465
- Controlsn = 465reference
- Outcome
- Prevalence of opioid therapy and LTOT (contiguous prescriptions with gaps <30 days and opioid therapy for ≥90 days or ≥10 prescriptions before the index date)
Methodological detailsmatched controls without SLE
- Matched controls without SLE
Main finding
As reported in the abstract
Receiving opioid therapy
P < 0.001
Observational data: associations, not effects.
Further findings
LTOT
Factors associated with long-term opioid therapy (LTOT) among patients with SLE
- Acute pericarditis, OR
- 3.92 (1.78-8.66) (95% CI)
- Fibromyalgia, OR
- 7.78 (3.89-15.55) (95% CI)
- Fragility fractures, OR
- 3.72 (1.25-11.07) (95% CI)
- Chronic low back pain, OR
- 4.00 (2.13-7.51) (95% CI)
- Mood disorders, OR
- 2.76 (1.47-5.16) (95% CI)
Opioid therapy and Area Deprivation Index
- No association between opioid therapy and Area Deprivation Index (ADI)
Original publication
Long-Term Opioid Therapy Among Patients With Systemic Lupus Erythematosus in the Community: A Lupus Midwest Network (LUMEN) Study. J Rheumatol. Published 15 November 2022. doi:10.
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