Lipid profile and N-terminal pro-brain natriuretic peptide (NT-proBNP) changes from pre-clinical to established rheumatoid arthritis: A 12 years follow-up explorative study
Authors' conclusion
Changes in the lipid profile and NT-proBNP in RA patients seem to be related to inflammation, with changes reflecting an increase in CVD risk occurring along with rises in CRP levels.
Study context
- Population
- Patients initially with arthralgia and RF and/or ACPA without arthritis who later developed rheumatoid arthritis (RA) and started bDMARDs
- Participants
- 38 consecutive patients
- Outcome
- Changes in lipid and NT-proBNP levels from pre-clinical stage and RA onset to bDMARD treatment
Methodological detailsconsecutive patients, longitudinal follow-up from pre-clinical stage through bDMARD treatment
- Consecutive patients
- Longitudinal follow-up from pre-clinical stage through bDMARD treatment
Main finding
As reported in the abstract
- CRP initially increased sharply, decreasing with the start of biological treatment
- Low-density lipoprotein-cholesterol (LDL-c) remained stable
- High-density lipoprotein-cholesterol (HDL-c) increased
- ApoA1, Lp(a), total cholesterol (TC)/HDL-c ratio and apolipoprotein B (ApoB) decreased during follow-up
- NT-proBNP closely followed progression of CRP
- TC, LDL-c, TC/HDL-c ratio, ApoA and ApoB inversely correlated with CRP; Lp(a) positively correlated
- HDL-c and triglycerides showed no correlation with CRP
Observational data: associations, not effects.
Original publication
Lipid profile and NT-proBNP changes from pre-clinical to established rheumatoid arthritis: A 12 years follow-up explorative study. Joint Bone Spine. Published 29 December 2023. doi:10.
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