Expansion of HLA‐DR Positive Peripheral Helper T and Naive B Cells in Anticitrullinated Protein Antibody‐Positive Individuals At Risk for Rheumatoid Arthritis
Authors' conclusion
The expansion of HLA-DR+ Tph cells and CXCR5-CD11c-CD38+ naive B cells in ACPA+ individuals, including those who developed inflammatory arthritis and classified RA, supports a key role of these cells in transition from pre-RA to classified RA.
Study context
- Population
- Anticitrullinated protein antibody (ACPA)+ individuals at risk for RA, ACPA+ early untreated RA and ACPA- controls (Tokyo and US cohorts)n = 17 in each group (Tokyo)
- Participants
- 17 / 17 / 17 / 11 / 9 / 11
- Comparison
- ACPA+ at-risk individuals and ACPA+ early untreated RA vs ACPA- controls
- ACPA+ at-riskn = 17
- Early RAn = 17
- ACPA- controlsn = 17reference
- Pre-RAn = 11
- Post-RAn = 9
- ACPA- controls (US)n = 11reference
- Outcome
- Immune cell populations in peripheral blood mononuclear cells
Methodological detailsmass cytometry (37 markers), flow cytometry validation cohort, longitudinal
- Mass cytometry (37 markers)
- Flow cytometry validation cohort
- Longitudinal
Main finding
As reported in the abstract
Immune cell expansion in PBMCs, Tokyo cohort
- HLA-DR+ Tph cells, activated regulatory T cells, PD-1hi CD8+ T cells and CXCR5-CD11c-CD38+ naive B cells significantly expanded in at-risk individuals and early RA
Further findings
Immune cell expansion, Targeting Immune Responses for Prevention of RA cohort · pre-RA and post-RA time points
- Expansion of HLA-DR+ Tph cells and CXCR5-CD11c-CD38+ naive B cells likewise found at both pre-RA and post-RA time points
Original publication
Expansion of HLA‐DR Positive Peripheral Helper T and Naive B Cells in Anticitrullinated Protein Antibody‐Positive Individuals At Risk for Rheumatoid Arthritis. Arthritis Rheumatol. Published 6 April 2024. doi:10.
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