Vasculitis & polymyalgia rheumatica
Limb arteries involvement assessed by FDG/PET CT at diagnosis of giant cell arteritis and risk of relapse: An observational study
Authors' conclusion
FDG uptake in limb arteries at diagnosis is a predictor of relapse in newly diagnosed GCA.
Study context
- Population
- Consecutive patients admitted with a new diagnosis of giant cell arteritis (GCA) (2022 ACR/EULAR classification criteria), May 2011–May 202298 FDG/PET CT scans reviewed
- Participants
- 108 patients
- Exposure
- FDG uptake in limb arteries at diagnosis as predictors of relapse
- Outcome
- GCA relapse rate
- Follow-up
- 36 months
Methodological detailsconsecutive patients, multivariable Cox regression, All patients received steroids for 21.0 [18.0-28.5] months, with MTX (n=1) or tocilizumab (n=2)
- Consecutive patients
- Multivariable Cox regression
- All patients received steroids for 21.0 [18.0-28.5] months, with MTX (n=1) or tocilizumab (n=2)
Main finding
As reported in the abstract
GCA relapse · median follow-up 27.5 [11.4-35.0] months
Relapse occurred
40
37%
FDG uptake in limb arteries at diagnosis, HR [CI] for relapse (multivariable Cox)
HR 2.7
1.3–5.5P<0.01
General signs at diagnosis, HR [CI] for relapse (multivariable Cox)
HR 2.0 [1.0-4.0, P<0.05
Observational data: associations, not effects.
Original publication
Limb arteries involvement assessed by FDG/PET CT at diagnosis of giant cell arteritis and risk of relapse: An observational study. Joint Bone Spine. Published 15 April 2024. doi:10.
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