Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus
Authors' conclusion
In serum from patients with cSLE different markers of endothelial activation were dysregulated. While most markers normalised during treatment, others remained elevated in a subset of patients, even during low disease activity.
Study context
- Population
- Multicentre longitudinal cohort of patients with childhood-onset SLE and age and sex comparable healthy controls (HC)47 cSLE, 42 HC analysed
- Participants
- 47 vs 42
- Exposure
- cSLE vs HC
- cSLEn = 47
- HCn = 42reference
- Outcome
- Serum levels of 15 EC markers and six lipids in cSLE vs HC
Methodological detailsmulticentre, age and sex comparable healthy controls
- Multicentre
- Age and sex comparable healthy controls
Main finding
As reported in the abstract
Serum EC markers, cSLE vs HC · t=1
- Angiopoietin-2, CCL2, CXCL10, GAS6, pentraxin-3, thrombomodulin, VCAM-1 and vWF-A2 elevated in cSLE vs HC at t=1
- Many elevated endothelial cell (EC) markers normalised over time after treatment; angiopoietin-2, CCL2, CXCL10, GAS6, thrombomodulin and VCAM-1 remained significantly increased vs HC
Observational data: associations, not effects.
Further findings
Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), median · t=1
- Median SLEDAI at t=1 (IQR 6-18)
- 12
EC markers over time after treatment, cSLE vs HC · t=2
- Many elevated EC markers at t=1 normalised over time after treatment
- Remained significantly increased vs HC: angiopoietin-2, CCL2, CXCL10, GAS6, thrombomodulin and VCAM-1
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Learning from serum markers reflecting endothelial activation: longitudinal data in childhood-onset systemic lupus erythematosus. Lupus Sci Med. Published 5 September 2024. doi:10.
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