Knee osteoarthritis bone shape from computed tomography is associated with subchondral bone attenuation and marginal cortical bone thickness: A cross-sectional study
Authors' conclusion
We uncovered a 3-D shape mode recognisable as osteoarthritic that was associated with radiographic disease status in patients with pre- to moderate knee OA and overweight. Increase in this shape mode was associated with greater cortical thickening at the joint margins, likely related to osteophytosis, and reduced subchondral trabecular attenuation, the implications of which are not yet understood.
Study context
- Population
- Individuals with knee OA (distal femur and proximal tibia segmented from Computed Tomography (CT) scans)133 CT scans
- Outcome
- Relationship between 3-D bone shape, cortical thickness (CTh) and trabecular attenuation (TA)
Methodological detailsstatistical shape modelling, cortical bone mapping, statistical parametric mapping, generalized estimating equations
- Statistical shape modelling
- Cortical bone mapping
- Statistical parametric mapping
- Generalized estimating equations
Main finding
As reported in the abstract
Shape mode 2 (SM2) associated with Kellgren-Lawrence-Grade (KLG), OR per SD
1.43
95% CI 1.28–1.59p<0.05
Cortical thickness (CTh) of marginal articular bone dependent on SM2, increase of up to … mm per SD (p<0.05)
0.2
Trabecular attenuation (TA) across nearly all femoral articular surface dependent on SM2, decrease of … HU per SD (p<0.05)
40
TA in posterolateral tibial plateau dependent on SM2, decrease of … HU per SD (p<0.05)
20
Observational data: associations, not effects.
Original publication
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