Lupus & antiphospholipid syndrome
Kidney-infiltrating proteinase 3-positive granulocytes are abundant in lupus nephritis
Authors' conclusion
PR3+ myeloid cells are a prominent and heterogeneous population in LN. While intraglomerular PR3+ cells were specific to proliferative LN and correlated with histologic activity, the widespread presence of PR3+ cells in the tubulointerstitium suggests broader involvement in renal inflammation than previously recognized.
Study context
- Population
- LN kidney biopsies
- Comparison
- Proliferative LN vs Membranous LN
- Outcome
- Distribution and cellular phenotype of PR3+ cells across renal tissue
Methodological detailsserial immunohistochemistry (10-plex), spatial transcriptomics
- Serial immunohistochemistry (10-plex)
- Spatial transcriptomics
Main finding
As reported in the abstract
PR3+ myeloid cells in LN kidneys
- Four subsets of PR3+ cells, consistent with a monocyte/neutrophil lineage
- 4
Original publication
Kidney-infiltrating proteinase 3-positive granulocytes are abundant in lupus nephritis. Rheumatology (Oxford). Published 17 July 2026. doi:10.
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