Spondyloarthritis & psoriatic arthritis
Interrelationships of disease activity, central sensitization, psychosocial and lifestyle factors in axial spondyloarthritis
Authors' conclusion
Our analyses exploring the interrelationships of biopsychosocial factors related to ASDAS showed that factors beyond inflammation, especially illness perception and central sensitization, seem to contribute significantly to ASDAS in patients treated for axSpA in our standard-of-care cohort
Study context
- Population
- Consecutive axial SpA (axSpA) patients from the prospective Groningen Leeuwarden axSpA (GLAS) cohort59% male
- Participants
- 332 patients
- Outcome
- Interrelationships of ASDAS with central sensitization, psychological and lifestyle factors (structural equation modelling (SEM))
Methodological detailsstructural equation modelling, consecutive patients from prospective GLAS cohort
- Structural equation modelling
- Consecutive patients from prospective GLAS cohort
Main finding
As reported in the abstract
Effects on ASDAS (final SEM model)
Model fit: root mean square error of approximation
0.057
95% CI 0.45–0.70
Model fit: comparative fit index
0.936
Observational data: associations, not effects.
Original publication
Interrelationships of disease activity, central sensitization, psychosocial and lifestyle factors in axial spondyloarthritis. Rheumatology (Oxford). Published 22 February 2025. doi:10.
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