Interosseous tendon inflammation in the hands of patients with clinically suspect arthralgia: analysis of MRI data from a prospective cohort study
Authors' conclusion
Interosseous tendon inflammation is almost absent in symptom-free individuals but occurs in people with clinically suspect arthralgia, in whom it correlates with symptoms and is associated with the development of clinical arthritis.
Study context
- Population
- Adults (≥18 years) with clinically suspect arthralgia and symptom-free controls undergoing contrast-enhanced hand MRIplus 3 embalmed bodies
- Participants
- 667 vs 193
- Exposure
- Clinically suspect arthralgia vs symptom-free controls
- Clinically suspect arthralgian = 667
- Symptom-free controlsn = 193reference
- Outcome
- Cross-sectional: presence of interosseous tendon inflammation on MRI; longitudinal: development of clinical arthritis
Methodological detailscross-sectional and longitudinal parts, contrast-enhanced hand MRI, symptom-free controls, cadaveric immunohistochemistry
- Cross-sectional and longitudinal parts
- Contrast-enhanced hand MRI
- Symptom-free controls
- Cadaveric immunohistochemistry
Main finding
As reported in the abstract
Presence of interosseous tendon inflammation on MRI (cross-sectional primary outcome) · At inclusion
P < 0.0001 vs symptom-free controls
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Clinical arthritis development in CSA, withvs without interosseous tendon inflammation · median total follow-up 25.3 months [95% CI 25.1-25.5] | 4.5 (2.8–7.2) | |
| 0.10.31310Hazard ratio (log scale) |
Interosseous tendon inflammation by MCP synovitis or tenosynovitis
| OR (95% CI) | ||
|---|---|---|
| Synovitis present | 2.2 (1.2–4.2) | |
| Tenosynovitis present | 9.7 (5.5–17.0) | |
| 0.050.21520Odds ratio (log scale) |
- Clinical arthritis development in CSA, with vs without interosseous tendon inflammation — CSA developing clinical arthritis
- 91 (16%) of 558
- Clinical arthritis development in CSA, with vs without interosseous tendon inflammation: after adjusting for concomitant synovitis, tenosynovitis, or osteitis: HR 1.7 [1.02-2.8]
Tenosynovium around interosseous tendons (cadaveric immunohistochemistry)
- No tenosynovium surrounding interosseous tendons
Original publication
Interosseous tendon inflammation in the hands of patients with clinically suspect arthralgia: analysis of MRI data from a prospective cohort study. Lancet Rheumatol. Published July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →