Vasculitis & polymyalgia rheumatica
Insights from comparison of serum IgG4 between T2-eosinophilic asthma and eosinophilic granulomatosis with polyangiitis/idiopathic hypereosinophilic syndrome
Authors' conclusion
Elevated serum IgG4 seemed to discriminate between T2-eosinophilic asthma "alone" and T2-eosinophilic asthma evolved into EGPA/iHES.
Study context
- Population
- Patients with T2-eosinophilic asthma or eosinophilic granulomatosis with polyangiitis (EGPA)/idiopathic hypereosinophilic syndrome (iHES), consecutively enrolled
- Participants
- 62 patients
- Comparison
- EGPA/iHES vs T2-eosinophilic asthma
- EGPA/iHESn = 35
- Asthmaticsn = 27reference
- Outcome
- Serum IgG4 (normal or elevated)
Methodological detailsretrospective/cross-sectional, consecutive enrolment
- Retrospective/cross-sectional
- Consecutive enrolment
Main finding
As reported in the abstract
Elevated serum IgG4
P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Mean serum IgG4 value | P = 0.010 |
Mean serum IgG4 value
- Mean serum IgG4 value higher in EGPA/iHES than asthmatics
Original publication
Insights from comparison of serum IgG4 between T2-eosinophilic asthma and eosinophilic granulomatosis with polyangiitis/idiopathic hypereosinophilic syndrome. Clin Exp Rheumatol. Published 8 April 2025. doi:10.
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