Influence of Obesity on Radiographic Changes in Patients With Diffuse Idiopathic Skeletal Hyperostosis
Authors' conclusion
One-third of patients with MetS were classified as having DISH. In contrast to degenerative spine disease, obese MetS classes II and III were significantly associated with radiographic spinal changes attributed to DISH.
Study context
- Population
- Patients diagnosed with metabolic syndrome (MetS); mean BMI 39.8 (SD 6.3)
- Exposure
- Diffuse idiopathic skeletal hyperostosis (DISH) vs non-DISH; obesity classes in MetS
- DISHn = 42
- Preobesen = 7
- Obesity class In = 19
- Obesity class IIn = 38
- Obesity class IIIn = 60
- Outcome
- Prevalence of DISH in MetS and influence of obesity on spinal radiographic changes (Drc- vs d-spondylophytes)
Main finding
As reported in the abstract
Prevalence of DISH
DISH
33.9%
42
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| Number of Drc-spondylophytes in DISH, obesity class ≥ II vs lower | Obesity class ≥ II (DISH) 14.8 (SD 10.3) · Lower obesity class (DISH) 9.7 (SD 7.7) | |
| Number of d-spondylophytes, DISH vs non-DISHFewer d-spondylophytes in DISH | DISH 2.7 (SD 2.7) · non-DISH 4.1 (SD 4.1) | P = 0.04 |
DISH-related chunky (Drc)-spondylophytes by obesity class, all patients
- Higher obesity classes (II and III) significantly associated with an increased number of Drc-spondylophytes in all patients
Number of Drc-spondylophytes in DISH, obesity class ≥ II vs lower
- No association between obesity and d-spondylophytes in DISH
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Influence of Obesity on Radiographic Changes in Patients With Diffuse Idiopathic Skeletal Hyperostosis. J Rheumatol. Published 1 July 2025. doi:10.
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