Spondyloarthritis & psoriatic arthritis
Inflammatory bowel disease does not confer higher disease activity or greater radiographic progression in axial spondyloarthritis
Main finding · Active axSpA (BASDAI ≥4)Result — go to the resultOdds ratio 0.98 95% CI 0.75–1.28Authors' conclusion
AxSpA-IBD patients exhibited distinct clinical features but did not have worse disease activity or greater radiographic progression than those with axSpA alone.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from a tertiary referral centre184 (13%) had inflammatory bowel disease (IBD)
- Participants
- 1,451 patients
- Exposure
- axSpA with IBD vs axSpA alone
- AxSpA-IBDn = 184
- Outcome
- Active axSpA (BASDAI ≥4) and radiographic progression (≥ 2-unit increase in modified Stoke Ankylosing Spondylitis Score (mSASSS) over 2 years)
Methodological detailssingle tertiary referral centre, generalized estimating equation models adjusted for key confounders, sensitivity analyses accounting for time-varying IBD status
- Single tertiary referral centre
- Generalized estimating equation models adjusted for key confounders
- Sensitivity analyses accounting for time-varying IBD status
Main finding
Active axSpA (BASDAI ≥4)
Odds ratio
0.98
95% CI 0.75–1.28
AxSpA-IBDvs AxSpA-only
OR 0.98 (95% CI 0.75–1.28)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Radiographic progression (≥ 2-unit increase in mSASSS over 2 years)Subset of 471 patients | 1.45 (0.78–2.73) | |
| 0.20.5125Odds ratio (log scale) |
Clinical features
- AxSpA-IBD had lower HLA-B27 positivity and higher rates of uveitis, peripheral arthritis and elevated CRP
Original publication
Inflammatory bowel disease does not confer higher disease activity or greater radiographic progression in axial spondyloarthritis. Rheumatology (Oxford). Published 18 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →