Lupus & antiphospholipid syndrome
Increased soluble CD200 in serum of systemic lupus erythematosus (SLE) patients does not reflect disease activity or affect CD200R1 function in T cells
Authors' conclusion
Our findings indicate that CD200R is a functional inhibitory receptor on T cells in SLE. In addition, we found that soluble CD200 in serum is increased in SLE but does not change during SLE flares.
Study context
- Population
- Patients with SLE, APS, pSS and SSc; prospective cohort of 100 SLE patients with two-year follow-upprospective cohort: 100 SLE
- Exposure
- SLE vs controls
Methodological detailscross-sectional cohort, prospective cohort with two-year follow-up, flow cytometry
- Cross-sectional cohort
- Prospective cohort with two-year follow-up
- Flow cytometry
Main finding
As reported in the abstract
- CD200R expression increased on T cells from SLE patients vs controls, but not in other interferonopathies
- CD200R ligation in vitro inhibited cytokine production by T cells from controls and SLE patients
- In SLE, serum sCD200 increased and soluble CD200R (sCD200R) decreased
- sCD200 increased in clinically active SLE; no correlation with disease flares within patients
Observational data: associations, not effects.
Original publication
Increased soluble CD200 in serum of SLE patients does not reflect disease activity or affect CD200R1 function in T cells. Arthritis Res Ther. Published 16 March 2026. doi:10.
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