Spondyloarthritis & psoriatic arthritis
Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors
Main finding · Incidence rate of recurrent CV eventsResult — go to the resultHazard ratio 0.33 95% CI 0.12–0.94Authors' conclusion
The incidence rate of recurrent cardiovascular events in patients with r-axSpA is substantial. TNFi exposure was associated with a lower risk of recurrent cardiovascular events.
Study context
- Population
- Patients with radiographic axial spondyloarthritis (r-axSpA) with a history of CV events (MI or stroke) after r-axSpA diagnosis, Korea
- Participants
- 413 patients
- Exposure
- Tumor necrosis factor inhibitors (TNFi) exposure vs TNFi non-exposure
- TNFi exposuren = 75
- TNFi non-exposuren = 338reference
- Outcome
- Recurrence of CV events:
- MI
- Stroke
Methodological detailsnationwide, Korean National Claims Database, inverse probability weighted Cox model
- Nationwide
- Korean National Claims Database
- Inverse probability weighted Cox model
Main finding
Incidence rate of recurrent CV events
Hazard ratio
0.33
95% CI 0.12–0.94
By group
TNFi exposurevs TNFi non-exposure
HR 0.33 (95% CI 0.12–0.94)
As reported in the abstract
- Overall incidence rate of recurrent CV events
- 32 per 1,000 person-years (95% CI 22-42)
Observational data: associations, not effects.
Original publication
Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors. Arthritis Res Ther. Published 4 October 2024. doi:10.
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