Incidence of Herpes Zoster in Patients With Rheumatoid Arthritis in the United States: A Retrospective Cohort Study
Main finding · Overall IR of HZResult — go to the resultAdjusted incidence rate ratio 1.93 95% CI 1.87–1.99Authors' conclusion
These results highlight the increased incidence of HZ in patients with RA.
Study context
- Population
- Patients aged ≥ 18 years, US administrative claims database, October 2015 to February 2020
- Participants
- 67,650 vs 11,401,743
- Exposure
- Rheumatoid arthritis (RA) vs no RA
- RAn = 67,650
- Non-RAn = 11,401,743reference
- Outcome
- Incidence of herpes zoster (HZ)
Methodological detailslongitudinal, administrative claims database (commercial and Medicare Advantage Part D), generalized linear models
- Longitudinal
- Administrative claims database (commercial and Medicare Advantage Part D)
- Generalized linear models
Main finding
Overall IR of HZ
Adjusted incidence rate ratio
1.93
95% CI 1.87–1.99
P < 0.001
By group
RA
21.5
per 1000 person-years
Non-RA
7.6
per 1000 PY
RAvs Non-RA
adjusted IRR 1.93 (95% CI 1.87–1.99); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
IR of HZ, age ≥ 65 yrs (highest IRs in both cohorts)
IR of herpes zoster (HZ) by medication class in RA
- Highest incidence rates (IRs) in patients using corticosteroids and those using JAKi
Original publication
Incidence of Herpes Zoster in Patients With Rheumatoid Arthritis in the United States: A Retrospective Cohort Study. J Rheumatol. Published 1 February 2023. doi:10.
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