Incidence of gout diagnosis among participants with hyperuricemia, insights from a nationwide cohort study
Authors' conclusion
Among participants with hyperuricemia, SU level stands out as the most important risk factor associated with significant increase in the incidence of gout.
Study context
- Population
- Adults aged 16 or older with at least two serum urate (SU) measurements >6.8 mg/dL, Clalit Health Insurance database, Israel, 2007–2022; prior gout or gout medications excluded
- Participants
- 301,385 hyperuricemic participants
- Exposure
- SU quartiles among hyperuricemic participants
- Outcome
- Gout diagnosis at least 90 days after the second record of hyperuricemia
Methodological detailsnationwide, Cox proportional hazards regression
- Nationwide
- Cox proportional hazards regression
Main finding
As reported in the abstract
Gout diagnosis
Diagnosed with gout after index date (overall)
15,055
5 %
Developed gout over 10 years, highest SU quartile
13 %
Annual incidence rate of gout, highest SU quartile
1.3 %
Observational data: associations, not effects.
Original publication
Incidence of gout diagnosis among participants with hyperuricemia, insights from a nationwide cohort study. Semin Arthritis Rheum. Published 12 June 2025. doi:10.
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