Calcium pyrophosphate deposition disease is associated with increased risk of fractures: A retrospective cohort study using electronic health record data
Main finding · Any fractureResult — go to the resultHazard ratio 1.29 95% CI 1.23–1.35Authors' conclusion
CPPD disease is associated with increased fracture risk across gender and fracture sites.
Study context
- Population
- Older adults (≥60 years) with CPPD disease and osteoarthritis (OA) vs OA alone, predominantly North American EHR data, 2005–2025 (mean age 73 years, 59% female)20,176 matched pairs
- Participants
- 20,176 vs 20,176
- Exposure
- CPPD plus OA vs OA alone
- CPPDn = 20,176
- OAn = 20,176reference
- Outcome
- Any fracture of spine, upper limb, lower limb
Methodological details1:1 propensity score-matched, Cox proportional hazards models, electronic health record data
- 1:1 propensity score-matched
- Cox proportional hazards models
- Electronic health record data
Main finding
Any fracture
Hazard ratio
1.29
95% CI 1.23–1.35
Events by group
CPPD
4015
events
OA
3349
events
CPPDvs OA
HR 1.29 (95% CI 1.23–1.35)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Any fracture in males (subgroup) | 1.36 (1.23–1.49) | |
| Any fracture in females (subgroup) | 1.30 (1.23–1.38) | |
| 0.512Hazard ratio (log scale) |
- Any fracture in males (subgroup): 1:1 propensity score-matched
- Any fracture in females (subgroup): 1:1 propensity score-matched
Sensitivity analyses excluding prior GC or anti-osteoporosis medication exposure or prior fracture
- Results were similar across all sensitivity analyses
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Calcium pyrophosphate deposition disease is associated with increased risk of fractures: A retrospective cohort study using electronic health record data. Osteoarthritis Cartilage. Published 6 June 2025. doi:10.
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