Incidence of first and subsequent fractures in multiple myeloma patients: a parallel cohort study using UK CPRD dataset
Authors' conclusion
MM patients are at higher risk of having an index fracture from 1 year pre-diagnosis and a subsequent vertebral fracture in the 2 years post-index fracture, compared to non-MM controls.
Study context
- Population
- UK primary care (CPRD GOLD), 1995–2017: Multiple Myeloma (MM) patients (54.7% male, median age 70 years) and matched non-MM controlsmatched cohort
- Participants
- 1,972 vs 6,413
- Exposure
- MM vs matched non-MM controls
- MMn = 1,972
- Non-MMn = 6,413reference
- Outcome
- Incidence of fracture at major osteoporotic sites (hip, vertebral, wrist or humerus)
- Follow-up
- Within 2 years before and after MM diagnosis
Methodological detailsage-, sex- and GP-practice-matched controls, UK CPRD GOLD primary care dataset, Cox proportional hazards models
- Age-, sex- and GP-practice-matched controls
- UK CPRD GOLD primary care dataset
- Cox proportional hazards models
Main finding
As reported in the abstract
Index fracture rate · from 1 year prior to MM diagnosis onwards
- Index fracture rate significantly greater in MM vs non-MM from 1 year prior to MM diagnosis onwards
- Matched cohort
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| Subsequent vertebral fracture · within 2 years post-index fracture | 8.16 (1.84–36.1) | P = 0.006 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
| Outcome | MM | Non-MM |
|---|---|---|
| Subsequent major fracture rate post-index fracture · up to 2 years | 14.7% (95% CI 11.4–20.5) | 14.6% (95% CI 10.8–19.2) |
Original publication
Incidence of first and subsequent fractures in multiple myeloma patients: a parallel cohort study using UK CPRD dataset. Osteoporos Int. Published 26 January 2026. doi:10.
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