Incidence and risk factors of major cardiovascular events in rheumatoid arthritis and psoriatic arthritis: A population-based cohort study
Main finding · First MACE, adjusted incidenceResult — go to the resultIncidence rate ratio 0.96 95 % CI 0.75–1.22Authors' conclusion
The incidence of MACE was similar in RA and PsA. Systemic inflammation and glucocorticoid use independently increased the risk of MACE in inflammatory arthritis, while methotrexate and NSAIDs use were protective against the development of MACE in RA.
Study context
- Population
- Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients recruited Jan 2006 to Dec 2015 from a citywide database, followed until end of 2018
- Participants
- 13,905 participants119,571 patient-years
- Exposure
- RA vs PsA
- RAn = 12,233
- PsAn = 1,672reference
- Outcome
- Occurrence of a first MACE
Methodological detailspopulation-based, citywide database, time-dependent Cox proportional hazard models
- Population-based
- Citywide database
- Time-dependent Cox proportional hazard models
Main finding
First MACE, adjusted incidence
Incidence rate ratio
0.96
95 % CI 0.75–1.22
P = 0.767
RAvs PsA
IRR 0.96 (95 % CI 0.75–1.22); P = 0.767
As reported in the abstract
- Patients developing a first major adverse cardiovascular events (MACE) (overall): 934
- 6.7%
Observational data: associations, not effects.
Further findings
Risk factors for MACE (adjusted for traditional cardiovascular (CV) risk factors)
- Time-varying ESR and C-reactive protein (CRP) levels independently associated with higher risk of MACE in both RA and PsA
- GC use independently associated with higher risk of MACE in both RA and PsA
- In RA, MTX and NSAID use associated with fewer MACE
- bDMARD use not associated with MACE in RA or PsA
Original publication
Incidence and risk factors of major cardiovascular events in rheumatoid arthritis and psoriatic arthritis: A population-based cohort study. Semin Arthritis Rheum. Published 15 February 2024. doi:10.
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