Vasculitis & polymyalgia rheumatica
Improved diagnostic accuracy for polymyalgia rheumatica using FDG-PET/CT with clinical diagnosis or 2012 ACR/EULAR classification criteria
Authors' conclusion
Combining FDG-PET/CT findings with the clinical baseline diagnosis or ACR/EULAR clinical classification criteria can improve the diagnostic specificity for PMR.
Study context
- Population
- Treatment-naïve patients suspected of PMR who received a clinical baseline diagnosis and FDG-PET/CT; investigation cohort 66/27 and validation cohort 36/21 PMR/non-PMR; final diagnosis at 12 or 6 months follow-up66/27 and 36/21 PMR/non-PMR
- Comparison
- Clinical baseline diagnosis or 2012 ACR/EULAR criteria, alone vs combined with FDG-PET/CT Leuven score
- Outcome
- Diagnostic accuracy (sensitivity/specificity) for PMR vs final diagnosis at clinical follow-up
- Follow-up
- 12 or six months
Methodological detailsinvestigation and validation cohort, two countries
- Investigation and validation cohort
- Two countries
Performance
As reported in the abstract
Sensitivity/specificity for PMR, investigation cohort · 12 months
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Clinical baseline diagnosis | 94% | 82% |
| ACR/EULAR criteria | 78% | 70% |
| Clinical baseline diagnosis + Leuven score | 80% | 93% |
| ACR/EULAR-Leuven score | 80% | 82% |
Sensitivity
Clinical baseline diagnosis94%
ACR/EULAR criteria78%
Clinical baseline diagnosis + Leuven score80%
ACR/EULAR-Leuven score80%
Specificity
Clinical baseline diagnosis82%
ACR/EULAR criteria70%
Clinical baseline diagnosis + Leuven score93%
ACR/EULAR-Leuven score82%
Further findings
Sensitivity/specificity for PMR, validation cohort · six months
Sensitivity
Specificity
Original publication
Improved diagnostic accuracy for polymyalgia rheumatica using FDG-PET/CT with clinical diagnosis or 2012 ACR/EULAR classification criteria. Rheumatology (Oxford). Published 26 July 2024. doi:10.
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