Lupus & antiphospholipid syndrome
Impact of deucravacitinib on arthritis in patients with systemic lupus erythematosus: results from the phase II PAISLEY systemic lupus erythematosus (SLE) study
Authors' conclusion
Deucravacitinib was associated with improvements in arthritis in patients in the phase II PAISLEY SLE study. Results will be further evaluated in ongoing phase III studies.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) with ≥6 swollen, tender or active (swollen plus tender) joints and those with any joint involvement at baseline
- Comparison
- Deucravacitinib versus placebo
Methodological details48-week, global, double-blind, placebo-controlled, phase II, non-responder imputation, logistic regression
- 48-week
- Global
- Double-blind
- Placebo-controlled
- Phase II
- Non-responder imputation
- Logistic regression
Primary result
As reported in the abstract
JC-100
- More patients achieved JC-100 with deucravacitinib versus placebo whether they had ≥1 or ≥6 tender or active joints at baseline
Further findings
JC-100 active joint responses in patients with ≥6 joints involved · week 48
| Outcome | Estimate |
|---|---|
| JC-100 for swollen, tender or active joints · week 48 | OR (swollen joints) 3.4 |
| JC-100 for swollen, tender or active joints · week 48 | OR (tender joints) 2.0 |
| JC-100 for swollen, tender or active joints · week 48 | OR (active joints) 3.3 |
JC-50 for swollen, tender or active joints
- Comparable responses and ORs were seen with achievement of JC-50 for swollen, tender or active joints at all deucravacitinib doses
Musculoskeletal score improvements by BILAG-2004 and SLEDAI-2K · week 48
- More patients receiving deucravacitinib versus placebo had musculoskeletal score improvements by both BILAG-2004 and SLEDAI-2K
Original publication
Impact of deucravacitinib on arthritis in patients with systemic lupus erythematosus: results from the phase II PAISLEY SLE study. Lupus Sci Med. Published 29 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →