Impact of early age at menopause on disease outcomes in postmenopausal women with rheumatoid arthritis: a large observational cohort study of Korean patients with rheumatoid arthritis
Main finding · Rate of SDAI change (GEE, patients with baseline SDAI >11)Result — go to the resultβ 1.265Authors' conclusion
Patients with RA and EM demonstrate higher disease activity and poorer HRQoL. Furthermore, EM significantly affects the longitudinal changes in disease activity and PROs in patients with RA.
Study context
- Population
- Postmenopausal women with rheumatoid arthritis (RA) from the Korean Observational Study Network for ArthritisGeneralised estimating equation (GEE) in baseline Simplified Disease Activity Index (SDAI) >11
- Participants
- 2,878 women
- Exposure
- Early menopause vs usual menopause
- Early menopause (EM)n = 437
- Usual menopause (UM)n = 2,441reference
- Outcome
- Longitudinal changes in RA activity (SDAI) and PROs (HAQ-DI and others)
- Follow-up
- 5 years
Methodological detailsobservational, multicentre registry (KORONA), generalised estimating equation analysis
- Observational
- Multicentre registry (KORONA)
- Generalised estimating equation analysis
Main finding
As reported in the abstract
Rate of SDAI change (GEE, patients with baseline SDAI >11)
β
1.265
P = 0.004
Observational data: associations, not effects.
Further findings
Baseline characteristics
- EM higher disease activity and worse patient-reported outcomes (PROs) for global assessment, fatigue, sleep disturbance and health-related quality of life (HRQoL)
- all p<0.05
- EM younger than UM
- RA duration similar between the two groups
- EM more educated and more likely seronegative at enrolment
Health Assessment Questionnaire-Disability Index (HAQ-DI) and EQ-5D-utility, longitudinal · 5-year follow-up
- EM significantly associated with increased HAQ-DI scores
- EM significantly associated with decreased EQ-5D-utility values
Original publication
Impact of early age at menopause on disease outcomes in postmenopausal women with rheumatoid arthritis: a large observational cohort study of Korean patients with rheumatoid arthritis. RMD Open. Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →