Hyperactivation and altered selection of B cells in patients with paediatric Sjogren’s syndrome
Authors' conclusion
Our results point to a hyperactivation of B cells in pSS.
Study context
- Population
- Patients with paediatric Sjögren's syndrome and age-comparable healthy donors
- Participants
- 17 vs 13
- Comparison
- Patients with Paediatric Sjögren's syndrome (pSS) vs age-comparable healthy donors
- pSSn = 17
- Controlsn = 13reference
- Outcome
- B cell and T cell phenotype, BAFF levels and selection of autoreactive B cells
Methodological detailscase-control, flow cytometry, ELISA
- Case-control
- Flow cytometry
- ELISA
Main finding
As reported in the abstract
- Relative frequency of total, transitional, naïve and switched memory B cells similar between pSS and controls
- pSS: reduced frequency of unswitched memory B cells
- pSS: increased frequency of atypical memory B cells
- pSS: expansion of PD1hi CXCR5- T peripheral helper cells
- BAFF levels higher in pSS vs controls; correlated with serum total IgG and anti-Ro titres
- Frequency of autoreactive B cells in transitional, unswitched memory and plasmablast compartments significantly higher in pSS vs controls
Original publication
Hyperactivation and altered selection of B cells in patients with paediatric Sjogren’s syndrome. RMD Open. Published 6 March 2024. doi:10.
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