Hydroxychloroquine exposure reduces the risk of cardiovasular disease events in patients with hypertension or diabetes mellitus
Main finding · CVD events (composite of AMI and ischaemic stroke)Result — go to the resultHazard ratio 0.67 95% CI 0.55–0.83Authors' conclusion
HCQ has protective effect on CVD events, including both AMI and ischaemic stroke in the patients with traditional risk factors. The protective effect of HCQ on CVD events is prominent in older patients.
Study context
- Population
- Patients with newly diagnosed hypertension (HTN) or diabetes mellitus (DM), without previous cardiovascular disease (CVD) events or invasive cardiovascular procedures, hospital-based population, 2010–2022146,862 with newly diagnosed HTN or DM
- Participants
- 1,903 vs 136,396
- Exposure
- Hydroxychloroquine (HCQ) exposure vs no HCQ exposure
- HCQn = 1,903
- Non-HCQn = 136,396reference
- Outcome
- CVD events, a composite of acute MI and ischaemic stroke
Methodological detailshospital-based population, adjusted for age, sex, rheumatic diseases, comorbidities and medications
- Hospital-based population
- Adjusted for age, sex, rheumatic diseases, comorbidities and medications
Main finding
As reported in the abstract
CVD events:
- Acute myocardial infarction (AMI)
- Ischaemic stroke
Hazard ratio
0.67
95% CI 0.55–0.83
HCQvs Non-HCQ
HR 0.67 (95% CI 0.55–0.83)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| AMIAdjusted | 0.61 (0.41–0.90) | |
| Ischaemic strokeAdjusted | 0.74 (0.59–0.93) | |
| CVD events, AMI and ischaemic stroke in older patients (age ≥50 yrs) (subgroup)HCQvs Non-HCQCVD events | 0.67 (0.54–0.83) | |
| CVD events, AMI and ischaemic stroke in older patients (age ≥50 yrs) (subgroup)HCQvs Non-HCQAMI | 0.67 (0.44–1.00) | |
| CVD events, AMI and ischaemic stroke in older patients (age ≥50 yrs) (subgroup)HCQvs Non-HCQIschaemic stroke | 0.71 (0.55–0.90) | |
| AMI in younger patients (age <50 yrs) (subgroup) | 0.28 (0.08–0.97) | |
| CVD events and ischaemic stroke in female patients (subgroup)HCQvs Non-HCQCVD events | 0.63 (0.48–0.82) | |
| CVD events and ischaemic stroke in female patients (subgroup)HCQvs Non-HCQIschaemic stroke | 0.63 (0.47–0.85) | |
| AMI in male patients (subgroup) | 0.44 (0.22–0.87) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Hydroxychloroquine exposure reduces the risk of cardiovasular disease events in patients with hypertension or diabetes mellitus. Clin Exp Rheumatol. Published 2 December 2022. doi:10.
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