Humoral responses against high-density lipoprotein are linked to unfavourable lipid and proteomic signatures in primary Sjögren’s disease—a multi-platform approach
Authors' conclusion
Humoral responses against HDL particles hallmark SjD, with different trajectories observed for functional and clinical correlates, probably linked to altered lipoprotein composition.
Study context
- Population
- Patients with Sjögren's disease (SjD), controls and lupus patients
- Participants
- 44 / 80 / 80
- Exposure
- SjD vs controls
- SjDn = 44
- Controlsn = 80reference
- Lupusn = 80
- Outcome
- IgG serum levels of anti-HDL and anti-ApoA1 antibodies
Methodological detailscase-control, validation cohort (lupus), multi-platform
- Case-control
- Validation cohort (lupus)
- Multi-platform
Main finding
As reported in the abstract
Anti-HDL and anti-ApoA1 IgG levels
- Levels in SjD comparable to those observed in lupus
- SjD vs Controls: both P < 0.010
Observational data: associations, not effects.
Further findings
Correlates of anti-HDL and anti-ApoA1
- Anti-HDL consistently associated with unfavourable lipoprotein and lipid profiles, proinflammatory cytokines and proteomic signatures linked to immune responses and tissue remodelling
- Anti-ApoA1 correlated with inflammation and disease activity
Atherosclerosis status in SjD
- Anti-HDL–lipidomic/proteomic relationships varied by atherosclerosis status; antibody levels did not differ
- Anti-HDL, but not anti-ApoA1, improved risk stratification over SCORE2
Original publication
Humoral responses against high-density lipoprotein are linked to unfavourable lipid and proteomic signatures in primary Sjögren’s disease—a multi-platform approach. Rheumatology (Oxford). Published 28 March 2026. doi:10.
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