Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence
Authors' conclusion
Both COA and AOA have a genetically causal effect on osteoporosis, and the risk of osteoporosis is greatly higher in AOA.
Study context
- Population
- Osteoporosis-free participants at baseline (2006–2010), UK BiobankUK Biobank
- Participants
- 478,289 participants
- Exposure
- Childhood-onset asthma and adult-onset asthma vs non-asthma
- Outcome
- Incident osteoporosis
Methodological detailstwo-sample Mendelian randomization, UK Biobank cohort, multivariate Cox regression
- Two-sample Mendelian randomization
- UK Biobank cohort
- Multivariate Cox regression
Main finding
As reported in the abstract
Incident osteoporosis (multivariate Cox regression)
Hazard ratio (95% CI)
COAvs Non-asthma
1.46(1.32–1.61)
AOAvs Non-asthma
1.70(1.61–1.80)
AOAvs COArisk greatly higher in AOA
1.51(1.34–1.70)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Genetically causal effect on osteoporosis (two-sample Mendelian randomization)COAvs Non-asthma | 1.007 (1.0003–1.0132) | |
| Genetically causal effect on osteoporosis (two-sample Mendelian randomization)AOAvs Non-asthma | 1.012 (1.002–1.023) | |
| 0.512Odds ratio (log scale) |
Incident osteoporosis by asthma medication monotherapy
| HR (95% CI) | ||
|---|---|---|
| Leukotriene modifiersIn addition to corticosteroids | 1.70 (1.20–2.42) | |
| Long-acting beta agonistsIn addition to corticosteroids | 1.49 (1.18–1.87) | |
| Short-acting beta agonistsIn addition to corticosteroids | 1.72 (1.01–2.93) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence. Osteoporos Int. Published 23 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →