Higher levels of VEGF-A and TNFα in patients with immune checkpoint inhibitor-induced inflammatory arthritis
Authors' conclusion
Elevated levels of VEGF-A and TNFα are associated with ICI-IA. There was also higher IL-6 and VEGF-A among those with higher disease activity when controlling for confounding.
Study context
- Population
- Immune checkpoint inhibitors (ICI)-treated cancer patients with ICI-induced inflammatory arthritis and ICI-treated controls
- Participants
- 80 / 17 / 19
- Exposure
- ICI-IA vs ICI-treated cancer controls without irAEs or with an unrelated irAE
- ICI-IAn = 80
- ICI-controls without irAEsn = 17reference
- ICI-controls with unrelated irAEn = 19reference
- Outcome
- Serum levels of 9 cytokines (IFN-γ, IL-4, IL-6, IL-10, IL-12p70, IL-1α, TNF-α, IL-17a, VEGF-A) in ICI-IA vs controls
Methodological detailscase-control comparison, multivariable ordinal logistic regression
- Case-control comparison
- Multivariable ordinal logistic regression
Main finding
As reported in the abstract
Serum cytokine levels, ICI-IA vs ICI-controls
- VEGF-A and TNFα significantly elevated in ICI-IA vs ICI-controls; persisted when restricted to patients not on immunosuppressants at sampling
Observational data: associations, not effects.
Further findings
Cytokines by IA severity (CDAI)
- Significantly higher VEGF-A in those with higher disease activity
- Ordinal logistic regression: higher IL-6 and VEGF-A associated with higher disease activity
Original publication
Higher levels of VEGF-A and TNFα in patients with immune checkpoint inhibitor-induced inflammatory arthritis. Arthritis Res Ther. Published 1 April 2025. doi:10.
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