Gender influence on ultrasound-assessed therapeutic response in rheumatoid arthritis: Insights from the GENder on UltraSound (GENUS) study
Authors' conclusion
These results suggest that the short-term ultrasound-assessed response to targeted therapy in RA patients is similar in women and men.
Study context
- Population
- Rheumatoid arthritis (RA) patients who initiated or switched targeted therapy174 evaluated at 3 months
- Participants
- 185 patients
- Exposure
- Women vs men with RA initiating or switching targeted therapy
- Womenn = 92
- Menn = 93reference
- Outcome
- Change in global US scores (B-mode synovitis, Doppler synovitis, Global EULAR-OMERACT Synovitis Score) from baseline
- Follow-up
- 3 months
Methodological detailsmulticentre, gender-balanced, women and men matched by age, blinded clinical, laboratory and US assessments, 11 patients lost to follow-up
- Multicentre
- Gender-balanced
- Women and men matched by age
- Blinded clinical, laboratory and US assessments
- 11 patients lost to follow-up
Main finding
As reported in the abstract
Change in global US scores
- No significant differences in changes in clinical, laboratory or US variables between genders
- p > 0.05
- Effect size small for all variables (Wilcoxon rank-sum test)
- r < 0.2
- Multivariate regression: no significant differences in US scores between women and men after adjustment for potential confounders
- p > 0.05
Observational data: associations, not effects.
Further findings
Change from baseline in most clinical, laboratory and US variables within each gender · 3 months
- Significant improvement in both women and men
- P < 0.01
- Large effect size for most variables in both genders (Wilcoxon signed-rank test)
- r ≥ 0.5
Original publication
Gender influence on ultrasound-assessed therapeutic response in rheumatoid arthritis: Insights from the GENder on UltraSound (GENUS) study. Semin Arthritis Rheum. Published 16 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →