Systemic sclerosis & Raynaud's
Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort
Authors' conclusion
SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered a risk factor for ILD progression.
Study context
- Population
- Systemic sclerosis (SSc) patients with interstitial lung disease (ILD) from the EUSTAR database
- Participants
- 5,462 patients
- Exposure
- SSc-ILD with gastroesophageal reflux disease (GERD) vs without GERD
- GERDn = 4,400
- Outcome
- Prevalence of GERD among SSc-ILD patients
Methodological detailsEUSTAR database, multivariable Cox regression
- EUSTAR database
- Multivariable Cox regression
Main finding
As reported in the abstract
Prevalence of GERD · baseline
GERD
80.6%
4400
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Diffuse cutaneous SSc · baseline | 1.44 (1.22–1.69) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | GERD | No GERD | P value |
|---|---|---|---|
| FVC · baseline | 85.8 ± 22.1 | 90.2 ± 20.1 | P < 0.001 |
| DLCO · baseline | 60.8 ± 19.7 | 65.3 ± 20.6 | P < 0.001 |
6-min walking test · baseline
- Worse performance with GERD
Predictors of ILD progression in SSc-ILD with GERD (multivariable Cox) · 12 ± 3 months
- Female sex, HR [1.07-1.80], P = 0.012
- 1.39
- Older age, HR [1.01-1.03], P < 0.001
- 1.02
Original publication
Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort. Rheumatology (Oxford). Published 8 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →