Systemic sclerosis & Raynaud's
Characterization of Incident Interstitial Lung Disease in Late Systemic Sclerosis
Main finding · Incident ILDResult — go to the resultRelative risk 0.68 95% CI 0.51–0.92Authors' conclusion
ILD can present in late SSc. Risk factors and progression rates overlapped with earlier-onset SSc-ILD.
Study context
- Population
- Canadian Scleroderma Research Group cohort participants, 2004 to 2020, without prevalent interstitial lung disease (ILD)
- Participants
- 969 participants
- Exposure
- Late systemic sclerosis (SSc) vs earlier SSc
- Outcome
- Incident ILD (on high-resolution computed tomography (HRCT))
Methodological detailsmulticentre registry cohort, Kaplan-Meier and multivariable Cox models
- Multicentre registry cohort
- Kaplan-Meier and multivariable Cox models
Main finding
Incident ILD
Relative risk
0.68
95% CI 0.51–0.92
By group
Late
3.7
incidence rate · /100 person-years
Latevs Earlier
RR 0.68 (95% CI 0.51–0.92)
As reported in the abstract
- Overall incident ILD, over a median of 2.4 (IQR 1.2-4.3) years
- 199 (21%) of 969
Observational data: associations, not effects.
Further findings
Lung disease severity in late- vs earlier-onset SSc-ILD
FVC
DLCO
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| ILD progression | 1.11 (0.58–2.10) | log rank P = 0.8 | |
| 0.512Hazard ratio (log scale) |
Lung disease severity in late- vs earlier-onset SSc-ILD
- Lung disease severity similar between late- and earlier-onset SSc-ILD
ILD progression
- Progression rates similar between late- and earlier-onset SSc-ILD
Risk factors for incident ILD
- Male sex, diffuse subtype, myositis, antitopoisomerase I autoantibodies and higher CRP
- Late-onset ILD: less frequently White, more frequently arthritis and anti-RNA-polymerase III autoantibodies
Original publication
Characterization of Incident Interstitial Lung Disease in Late Systemic Sclerosis. Arthritis Rheumatol. Published 7 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →