Fragility fractures in lupus patients: Associated factors and comparison of four fracture risk assessment tools
Authors' conclusion
OP is a common comorbidity in SLE patients, even in younger patients. FF appears to be more frequent in patients with hematologic involvement. The comparison of the four algorithms shows that DeFRA is the most accurate tool
Study context
- Population
- Women with systemic lupus erythematosus (SLE) who underwent BMD assessment by DXA within 3 months of their last visit
- Participants
- 86 women
- Exposure
- Four fracture risk assessment tools: DeFRA, FRAX, GARVAN and QFracture
- Outcome
- Prevalence of OP and fragility fractures
Main finding
As reported in the abstract
Osteoporosis (OP)
33
38.4%
Fragility fractures
13
15.1%
Observational data: associations, not effects.
Further findings
| Outcome | DeFRA | FRAX GC | GARVAN | QFracture | R |
|---|---|---|---|---|---|
| Median 10-year risk of major fragility fracture by tool · 10 yearsFRAX GC vs DeFRA · DeFRA was the best tool for this population | 9.85 (IQR 8.6) | 8.8 (IQR 11.7) | 12 (IQR 8.2) | 4.1 (IQR 5.8) | 0.85 |
| AUC | 0.94 (p < .0001, CI 0.88-1) | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
- Median 10-year risk of major fragility fracture by tool: best correlation; significant correlation among all instruments (p < .0001)
Factors associated with fragility fractures (univariate analysis)
- Thrombocytopenia
- P = 0.01
- Hemolytic anemia
- P = 0.0001
- Cyclosporine A intake
- P = 0.002
- CYC intake
- P = 0.006
- RTX intake
- P = 0.001
Median T-score
- Femoral neck
- −1.6 (IQR 0.9)
- Lumbar spine
- −1.7 (IQR 1.1)
Original publication
Fragility fractures in lupus patients: Associated factors and comparison of four fracture risk assessment tools. Lupus. Published 12 September 2023. doi:10.
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