Fibrotic disease co-occurrence and associated risk of subsequent organ failure: a nationwide matched cohort study
Main finding · Organ failureResult — go to the resultHazard ratio 1.20 95% CI 1.18–1.22Authors' conclusion
Fibrotic diseases frequently co-occur and are associated with an increased risk of organ failure, which support the concept of a partially shared systemic fibrotic hypothesis
Study context
- Population
- Adults in Danish nationwide health registries with a first-time diagnosis of any of nine major fibrotic diseases, 1998–2024 (median age 57 years; 54% female)matched cohort
- Participants
- 328,344 vs 985,032
- Exposure
- Individuals with a fibrotic disease vs matched controls
- Fibrotic diseasen = 328,344
- Controlsn = 985,032reference
- Outcome
- Risk of developing an organ failure
- Follow-up
- Median 10 years
Methodological detailsregistry-based (Danish nationwide health registries), matched controls, multivariable Cox proportional hazards models, logistic regression for co-occurrence
- Registry-based (Danish nationwide health registries)
- Matched controls
- Multivariable Cox proportional hazards models
- Logistic regression for co-occurrence
Main finding
Organ failure
Hazard ratio
1.20
95% CI 1.18–1.22
Fibrotic diseasevs Controls
HR 1.20 (95% CI 1.18–1.22)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Co-occurrence of fibrotic diseases: carpal tunnel syndrome and trigger finger (strongest association)Carpal tunnel syndromevs Trigger finger | 6.05 (5.94–6.15) | |
| 0.10.31310Odds ratio (log scale) |
- Co-occurrence of fibrotic diseases: carpal tunnel syndrome and trigger finger (strongest association): adjusted for sex, birth year, time-at-risk, educational level and ethnicity
Co-occurrence of fibrotic diseases: carpal tunnel syndrome and trigger finger (strongest association)
- Most fibrotic diseases were associated with an increased odds of co-occurring fibrotic diseases
Original publication
Fibrotic disease co-occurrence and associated risk of subsequent organ failure: a nationwide matched cohort study. Rheumatology (Oxford). Published 4 April 2026. doi:10.
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