Vasculitis & polymyalgia rheumatica
Fibroblast activation protein inhibitor-positron emission tomography in aortitis: fibroblast pathology in active inflammation and remission
Authors' conclusion
This pilot feasibility study shows significant tracer uptake in the aortic walls in LVV. FAPI positivity indicates ongoing fibroblast pathology in clinically remitted LVV.
Study context
- Population
- Large vessel vasculitis (LVV) patients with aortitis (3 clinically active, 5 in remission) and age- and gender-matched controls
- Participants
- 8 vs 8
- Comparison
- LVV with aortitis vs age- and gender-matched controls
- Aortitisn = 8
- Controlsn = 8reference
- Outcome
- Fibroblast activation in vessel walls detected by FAPI-PET/CT
Methodological detailsage- and gender-matched controls, FAPI-PET/CT
- Age- and gender-matched controls
- FAPI-PET/CT
Main finding
As reported in the abstract
- Irrespective of activity, FAPI uptake significantly enhanced in aortitis vs controls
Further findings
- Remitted aortitis: visually identifiable FAPI uptake
- 4/5 · events
Remitted aortitis: visually identifiable FAPI uptake
- Significant FAPI uptake in vessel wall despite mean remission duration of 2.8 years (range 1-4 years)
- MRI inflammatory scores close to negative in remitted aortitis
Original publication
Fibroblast activation protein inhibitor-positron emission tomography in aortitis: fibroblast pathology in active inflammation and remission. Rheumatology (Oxford). Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →