Femoral neck shape and trabecular bone microarchitecture association with hip osteoarthritis – Results from the QUALYOR study
Authors' conclusion
Women with hip OA have larger femoral neck and lower trabecular bone parameters, suggesting a sizeable role of hip bone geometry and remodeling in the pathophysiology of hip OA.
Study context
- Population
- Postmenopausal women in the QUALYOR prospective cohort; mean age 65.9 (±6.7) years, mean BMI 24.6 (±3.6) kg/m²
- Participants
- 1,537 postmenopausal women
- Exposure
- Women with hip osteoarthritis (OA) vs without hip OA
- No OAn = 601reference
- Mild OAn = 756
- Severe OAn = 180
- Outcome
- Bone characteristics (DXA areal BMD, hip quantitative computerized tomography (QCT) vBMD and geometry, HR-pQCT microarchitecture) associated with hip OA
- Follow-up
- Baseline
Methodological detailscross-sectional analysis of the QUALYOR prospective cohort, multivariable modeling
- Cross-sectional analysis of the QUALYOR prospective cohort
- Multivariable modeling
Main finding
As reported in the abstract
Bone characteristics in women with vs without hip OA
Hip OA vs No OABetween group difference (radius trabecular area), mm2 (95% CI)P value
205.11 vs. 192.61mm2
12.50(8.15–16.86)
P < 0.01Hip OA vs No OABetween group difference (tibia trabecular number), /μm (95% CI)P value
1.57/μmvs 1.63/μm
−0.06(−0.09 to −0.03)
P < 0.001Hip OA vs No OABetween group difference (tibia trabecular spacing), μm (95% CI)P value
0.58 vs. 0.56μm
0.02(0.011–0.038)
P < 0.005- Trabecular total hip vBMD lower with hip OA (125 vs. 129mg/cm³)
- P < 0.01
- Cortical hip vBMD did not differ with vs without hip OA (966.5 vs. 963.5mg/cm³)
- P n.s
- Larger femoral neck volume with hip OA (11.55 vs. 11.27mm3)
- P < 0.001
- Greater femoral neck bending resistance in mild hip OA: CSMI min 6.03 vs. 5.6cm4; Z polar 7.98 vs. 7.59cm3; even greater in severe hip OA
- P < 0.05
Observational data: associations, not effects.
Original publication
Femoral neck shape and trabecular bone microarchitecture association with hip osteoarthritis – Results from the QUALYOR study. Joint Bone Spine. Published 30 April 2025. doi:10.
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