‘Fast Ossifier’ in diffuse idiopathic skeletal hyperostosis: a sex-modulated, heterogeneous phenotype with accelerated ossification and early trabecular decline
Authors' conclusion
FO represents an active variant that challenges the view of DISH as a quiescent disease affecting older men.
Study context
- Population
- Diffuse idiopathic skeletal hyperostosis (DISH) cases and matched controls in the Camargo Cohort455 DISH cases · 455 matched controls
- Participants
- 61 vs 455
- Comparison
- Fast Ossifiers vs matched controls
- Fast Ossifiers (FO)n = 61
- Controlsn = 455reference
- Outcome
- Clinical profile of Fast Ossifiers (inflammation, insulin resistance via TyG, Visceral Adiposity Index (VAI), iPTH, BTM, Trabecular Bone Score (TBS))
Methodological detailspropensity-score matched, cross-sectional and longitudinal data (E0, 5 year E1, 10 year E2)
- Propensity-score matched
- Cross-sectional and longitudinal data (E0, 5 year E1, 10 year E2)
Main finding
As reported in the abstract
TyG
FO
8.65
± 0.9
Controls
8.39
± 0.4
P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| FO association with high TyG (multivariable) | 9.31 (1.04–36) | P = 0.046 | |
| FO association with low TBS (multivariable) | 0.002 (0.001–0.61) | ||
| 0.050.21520Adjusted odds ratio (log scale) |
Alkaline phosphatase
P = 0.043
| Outcome | FO | Controls | P value |
|---|---|---|---|
| VAI in FO-femalesFemales | 2.30 ± 2 | 1.44 ± 0.1 | P = 0.024 |
Intact parathormone (iPTH) at E2
- Elevated iPTH at E2 in both sexes
Original publication
‘Fast Ossifier’ in diffuse idiopathic skeletal hyperostosis: a sex-modulated, heterogeneous phenotype with accelerated ossification and early trabecular decline. RMD Open. Published 21 September 2025. doi:10.
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