Trabecular bone score in glucocorticoid-induced osteoporosis: A systematic review and meta-analysis
Pooled result · TBSResult — go to the resultSMD −0.47 95% CI −0.64 to −0.31Authors' conclusion
GC exposure is associated with significant and consistent deterioration in TBS across diverse subgroups.
Study context
- Population
- Studies assessing trabecular bone score (TBS) and areal BMD in glucocorticoid (GC)-treated patients and non-GC controls
- Participants
- 3,215 participants8 studies
- Comparison
- GC-treated patients vs non-GC controls
- Outcome
- TBS
Methodological detailsrandom effects model, subgroup and sensitivity analyses, Databases searched until December 2024, Risk of bias assessed with the Joanna Briggs Institute Checklist
- Random effects model
- Subgroup and sensitivity analyses
- Databases searched until December 2024
- Risk of bias assessed with the Joanna Briggs Institute Checklist
Pooled result
As reported in the abstract
SMD
−0.47
95% CI −0.64 to −0.31
P < 0.00001
GC-treatedvs Controls
SMD −0.47 (95% CI −0.64 to −0.31); P < 0.00001
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| LS aBMD | −0.1784 (−0.3190 to −0.0378) | P = 0.01 | |
| Total hip aBMDBorderline reduction | −0.2686 (−0.5353 to −0.0019) | P = 0.05 | |
| −1−0.500.5Difference (linear scale) |
Femoral neck areal bone mineral density (aBMD)
- No significant difference (P = 0.06)
Lumbar spine (LS)-aBMD in females (subgroup)
- Significantly lower LS-aBMD in females, SMD
- −0.25 (95% CI −0.39, −0.11; P = 0.0005)
LS-aBMD in White population (subgroup)
- Significantly lower LS-aBMD in White population, SMD
- −0.20 (95% CI −0.38, −0.03; P = 0.03)
TBS by sex, ethnicity and BMI (subgroups)
- TBS significantly lower regardless of sex, ethnicity and BMI
Original publication
Trabecular bone score in glucocorticoid-induced osteoporosis: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 15 May 2026. doi:10.
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