Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults
Authors' conclusion
Family history of several related conditions was associated with increased risk for arthritis, osteoporosis, and carpal tunnel syndrome
Study context
- Population
- Participants in the All of Us (AoU) Research Program, US adults
- Participants
- 156,307 participants
- Exposure
- Self-reported first-degree family history vs no family history of arthritis, osteoporosis or carpal tunnel syndrome
- Outcome
- Prevalence of fibromyalgia, gout, OA, RA, SLE, osteoporosis and carpal tunnel syndrome by first-degree family history (odds ratios (ORs))
Methodological detailsstratified analyses by race and ethnicity, sex, socioeconomic differences, BMI and type of affected relative
- Stratified analyses by race and ethnicity, sex, socioeconomic differences, BMI and type of affected relative
Main finding
As reported in the abstract
Prevalence of conditions by family history (ORs)
Family history of the same condition, OR range (average)
3.68 to 7.59
4.90, on average
Family history of a different condition, OR range (average)
0.70 to 2.10
1.24, on average
Family history of OA and prevalence of OA, OR
7.59 (7.32-7.88) (95% CI)
Family history of SLE and prevalence of SLE, OR
6.34 (5.17-7.74) (95% CI)
Observational data: associations, not effects.
Further findings
Family history of any arthritis, osteoporosis or carpal tunnel syndrome
- Proportion of AoU participants reporting a family history
- More than 38%
Stratified analyses
- Race and ethnicity and sex disparities in family history associations
Original publication
Family History of Arthritis, Osteoporosis, and Carpal Tunnel Syndrome and Risk of These Conditions Among US Adults. Arthritis Care Res (Hoboken). Published 18 September 2024. doi:10.
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